CD79A (CD79a molecule)

2007-02-01  

Identity

HGNC
CD79A
LOCATION
19q13.2
LOCUSID
973
ALIAS
IGA,MB-1

Other Information

Locus ID:

NCBI: 973
MIM: 112205
HGNC: 1698
Ensembl: ENSG00000105369

Variants:

dbSNP: 973
ClinVar: 973
TCGA: ENSG00000105369
COSMIC: CD79A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105369ENST00000221972P11912
ENSG00000105369ENST00000444740P11912
ENSG00000105369ENST00000597454M0QX61

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
B cell receptor signaling pathwayKEGGko04662
Primary immunodeficiencyKEGGko05340
B cell receptor signaling pathwayKEGGhsa04662
Primary immunodeficiencyKEGGhsa05340
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
CD22 mediated BCR regulationREACTOMER-HSA-5690714

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362411552023Selective IgA Deficiency May Be an Underrecognized Risk Factor for Severe COVID-19.4
362889812023Galactose-deficient IgA1 Is Involved in IgA Deposition in Renal Grafts Biopsied One Hour after Kidney Transplantation.1
364690242023Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function.4
375205412023Immunoglobulin A levels and its correlation with neutrophil-to-lymphocyte ratio as inflammatory biomarkers for dry eye disease in type 2 diabetes: a retrospective study.4
362411552023Selective IgA Deficiency May Be an Underrecognized Risk Factor for Severe COVID-19.4
362889812023Galactose-deficient IgA1 Is Involved in IgA Deposition in Renal Grafts Biopsied One Hour after Kidney Transplantation.1
364690242023Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function.4
375205412023Immunoglobulin A levels and its correlation with neutrophil-to-lymphocyte ratio as inflammatory biomarkers for dry eye disease in type 2 diabetes: a retrospective study.4
364269422022Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression.13
364269422022Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression.13
334524462021CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.16
334524462021CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.16
326415982020Clinicopathological significance of CD79a expression in classic Hodgkin lymphoma.10
326415982020Clinicopathological significance of CD79a expression in classic Hodgkin lymphoma.10
303961842019RUNX1 Mutations Can Lead to Aberrant Expression of CD79a and PAX5 in Acute Myelogenous Leukemias: A Potential Diagnostic Pitfall.2

Citation

Dessen P

CD79A (CD79a molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43891/haematological-explorer/js/css/template-card.css