PRSS1 (serine protease 1)

2007-02-01 Affiliation

Identity

HGNC

PRSS1

LOCATION

7q34

LOCUSID

5644

ALIAS

TRP1,TRY1,TRY4,TRYP1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5644
MIM: 276000
HGNC: 9475
Ensembl: ENSG00000204983

Variants:

dbSNP: 5644
ClinVar: 5644
TCGA: ENSG00000204983
COSMIC: PRSS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204983	ENST00000311737	P07477
ENSG00000204983	ENST00000486171	E7EQ64
ENSG00000204983	ENST00000492062	H0Y8D1
ENSG00000204983	ENST00000619214	A6XGL3

Expression (GTEx)

10000

20000

30000

40000

50000

60000

70000

80000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
Protein digestion and absorption	KEGG	ko04974
Protein digestion and absorption	KEGG	hsa04974
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Metabolism	REACTOME	R-HSA-1430728
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	REACTOME	R-HSA-196849
Cobalamin (Cbl, vitamin B12) transport and metabolism	REACTOME	R-HSA-196741
Extracellular matrix organization	REACTOME	R-HSA-1474244
Degradation of the extracellular matrix	REACTOME	R-HSA-1474228
Activation of Matrix Metalloproteinases	REACTOME	R-HSA-1592389

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15017610	2004	Clinical and genetic characteristics of hereditary pancreatitis in Europe.	128
23143602	2012	Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.	78
18755888	2009	The natural history of hereditary pancreatitis: a national series.	69
18184119	2008	Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series.	57
18184119	2008	Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series.	57
22427236	2013	CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?	53
11932257	2002	Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis.	45
22539344	2012	Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C.	34
12360463	2002	Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations.	32
25253127	2015	Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.	28

Citation

Dessen P

PRSS1 (serine protease 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43895/prss1