FDPS (farnesyl diphosphate synthase)

2007-02-01  

Identity

HGNC
FDPS
LOCATION
1q22
LOCUSID
2224
ALIAS
FPPS,FPS,POROK9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2224
MIM: 134629
HGNC: 3631
Ensembl: ENSG00000160752

Variants:

dbSNP: 2224
ClinVar: 2224
TCGA: ENSG00000160752
COSMIC: FDPS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160752ENST00000356657P14324
ENSG00000160752ENST00000368356P14324
ENSG00000160752ENST00000447866P14324
ENSG00000160752ENST00000465559A0A087X1D8
ENSG00000160752ENST00000467076P14324
ENSG00000160752ENST00000474345A0A087WTP2
ENSG00000160752ENST00000491013A0A087WVN4
ENSG00000160752ENST00000611010A0A087X090
ENSG00000160752ENST00000612683P14324

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Terpenoid backbone biosynthesisKEGGko00900
Terpenoid backbone biosynthesisKEGGhsa00900
Metabolic pathwaysKEGGhsa01100
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Cholesterol biosynthesisREACTOMER-HSA-191273
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10235zoledronateChemicalClinicalAnnotationassociatedPD21196316
PA164712563BisphosphonatesChemicalClinicalAnnotationassociatedPD18687167, 21151198, 24311107
PA443797Coronary DiseaseDiseaseClinicalAnnotationassociatedPD21151198, 24311107
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD21196316
PA445187OsteonecrosisDiseaseClinicalAnnotationassociatedPD21196316
PA445190OsteoporosisDiseaseClinicalAnnotationassociatedPD18687167, 21151198, 24311107
PA446214Osteoporosis, PostmenopausalDiseaseClinicalAnnotationassociatedPD18687167, 21151198
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD21151198, 24311107

References

Pubmed IDYearTitleCitations
388918102024Farnesyl Diphosphate Synthase Gene Associated with Loss of Bone Mass Density and Alendronate Treatment Failure in Patients with Primary Osteoporosis.0
388918102024Farnesyl Diphosphate Synthase Gene Associated with Loss of Bone Mass Density and Alendronate Treatment Failure in Patients with Primary Osteoporosis.0
373103962023Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis.1
373103962023Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis.1
347511462021Novel missense mutations of MVK and FDPS gene in Chinese patients with disseminated superficial actinic porokeratosis.2
348857212021Towards an Improvement of Anticancer Activity of Benzyl Adenosine Analogs.0
347511462021Novel missense mutations of MVK and FDPS gene in Chinese patients with disseminated superficial actinic porokeratosis.2
348857212021Towards an Improvement of Anticancer Activity of Benzyl Adenosine Analogs.0
305610512019A novel premature termination mutation in FDPS in a Chinese family with disseminated superficial actinic porokeratosis.1
309148012019FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.31
317748732019Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women.7
305610512019A novel premature termination mutation in FDPS in a Chinese family with disseminated superficial actinic porokeratosis.1
309148012019FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.31
317748732019Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women.7
293370592018FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway.17

Citation

Dessen P

FDPS (farnesyl diphosphate synthase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43907/js/lib/css/template-card.css