PGGT1B (protein geranylgeranyltransferase type I subunit beta)

2007-02-01  

Identity

HGNC
PGGT1B
LOCATION
5q22.3
LOCUSID
5229
ALIAS
BGGI,GGTI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5229
MIM: 602031
HGNC: 8895
Ensembl: ENSG00000164219

Variants:

dbSNP: 5229
ClinVar: 5229
TCGA: ENSG00000164219
COSMIC: PGGT1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164219ENST00000379615P53609
ENSG00000164219ENST00000419445P53609

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
335481092021The diagnostic significance of PGGT1B in psoriasis.0
335481092021The diagnostic significance of PGGT1B in psoriasis.0
234753912013Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion.3
234753912013Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion.3
221603082012Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.29
221603082012Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.29
204039972010Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.35
204469222010Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.8
204039972010Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.35
204469222010Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.8
196672182009Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.28
196672182009Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.28
154516702004Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.112
154516702004Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.112
145988912003Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.19

Citation

Dessen P

PGGT1B (protein geranylgeranyltransferase type I subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43928/js/css/lib/favicon/apple-touch-icon.png