ATP2B2 (ATPase plasma membrane Ca2+ transporting 2)

2007-02-01  

Identity

HGNC
LOCATION
3p25.3
LOCUSID
ALIAS
PMCA2,PMCA2a,PMCA2i
FUSION GENES

Other Information

Locus ID:

NCBI: 491
MIM: 108733
HGNC: 815
Ensembl: ENSG00000157087

Variants:

dbSNP: 491
ClinVar: 491
TCGA: ENSG00000157087
COSMIC: ATP2B2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157087ENST00000352432A0A2U3TZI3
ENSG00000157087ENST00000360273Q01814
ENSG00000157087ENST00000360273A0A024R2K6
ENSG00000157087ENST00000397077Q01814
ENSG00000157087ENST00000397077A0A024R2E4
ENSG00000157087ENST00000452124Q01814
ENSG00000157087ENST00000460129Q01814
ENSG00000157087ENST00000467702A0A2R8Y535
ENSG00000157087ENST00000638646A0A2U3U055
ENSG00000157087ENST00000643662Q01814
ENSG00000157087ENST00000644553A0A2R8Y4R4
ENSG00000157087ENST00000644807Q01814
ENSG00000157087ENST00000645850Q01814
ENSG00000157087ENST00000645850A0A024R2K6
ENSG00000157087ENST00000646379Q01814
ENSG00000157087ENST00000646379A0A024R2E4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Calcium signaling pathwayKEGGhsa04020
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Reduction of cytosolic Ca++ levelsREACTOMER-HSA-418359
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172348112007A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.39
126240872003Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targeting.38
198502832010Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.27
162162242005Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines.22
209711182011Ca efflux via the sarcolemmal Ca ATPase occurs only in the t-tubules of rat ventricular myocytes.18
202118632010Endothelial nitric oxide synthase activity is inhibited by the plasma membrane calcium ATPase in human endothelial cells.17
206638962010Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells.17
217571852011Converging evidence for an association of ATP2B2 allelic variants with autism in male subjects.17

Citation

Dessen P

ATP2B2 (ATPase plasma membrane Ca2+ transporting 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43952/atp2b2-(atpase-plasma-membrane-ca2+-transporting-2)