TLR6 (toll like receptor 6)

2007-02-01  

Identity

HGNC
TLR6
LOCATION
4p14
LOCUSID
10333
ALIAS
CD286
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10333
MIM: 605403
HGNC: 16711
Ensembl: ENSG00000174130

Variants:

dbSNP: 10333
ClinVar: 10333
TCGA: ENSG00000174130
COSMIC: TLR6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174130ENST00000381950Q9Y2C9
ENSG00000174130ENST00000436693Q9Y2C9
ENSG00000174130ENST00000508254D6RAV7
ENSG00000174130ENST00000514655D6R979
ENSG00000174130ENST00000610323Q9Y2C9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR2/4)REACTOMER-HSA-5603041
MyD88 deficiency (TLR2/4)REACTOMER-HSA-5602498
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Regulation of TLR by endogenous ligandREACTOMER-HSA-5686938

References

Pubmed IDYearTitleCitations
372328142023High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma.2
372328142023High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma.2
345636102022Variants of Toll-like receptor 6 associated with tuberculosis susceptibility in the Chinese Tibetan population.1
345636102022Variants of Toll-like receptor 6 associated with tuberculosis susceptibility in the Chinese Tibetan population.1
339373942021Sequence and Structural Characterization of Toll-Like Receptor 6 from Human and Related Species.2
342753412021Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population.3
339373942021Sequence and Structural Characterization of Toll-Like Receptor 6 from Human and Related Species.2
342753412021Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population.3
330667542020Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets.10
330667542020Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets.10
310844312019Toll-like receptors 2 and 6 mediate apoptosis and inflammation in ischemic skeletal myotubes.2
310844312019Toll-like receptors 2 and 6 mediate apoptosis and inflammation in ischemic skeletal myotubes.2
291122962018Live Faecalibacterium prausnitzii induces greater TLR2 and TLR2/6 activation than the dead bacterium in an apical anaerobic co-culture system.12
291753922018Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.2
300285332018Toll-like receptor 1, 2 and 6 polymorphisms: no association with 11 serum cytokine concentrations.0

Citation

Dessen P

TLR6 (toll like receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43954/tumors-explorer/css/lib/dataTables.bootstrap.min.css