SLC4A2 (solute carrier family 4 member 2)

2007-02-01  

Identity

HGNC
SLC4A2
LOCATION
7q36.1
LOCUSID
6522
ALIAS
AE2,BND3L,EPB3L1,HKB3,NBND3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6522
MIM: 109280
HGNC: 11028
Ensembl: ENSG00000164889

Variants:

dbSNP: 6522
ClinVar: 6522
TCGA: ENSG00000164889
COSMIC: SLC4A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164889ENST00000392826P04920
ENSG00000164889ENST00000413384P04920
ENSG00000164889ENST00000461735P04920
ENSG00000164889ENST00000463414C9J035
ENSG00000164889ENST00000482950C9JVC2
ENSG00000164889ENST00000483786C9J722
ENSG00000164889ENST00000485713P04920
ENSG00000164889ENST00000488420C9J459
ENSG00000164889ENST00000490898C9J9M9

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Bicarbonate transportersREACTOMER-HSA-425381

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363439202023SLC4A2, another gene involved in acid-base balancing machinery of osteoclasts, causes osteopetrosis.2
372707782023Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2.3
363439202023SLC4A2, another gene involved in acid-base balancing machinery of osteoclasts, causes osteopetrosis.2
372707782023Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2.3
337276332021Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)/HCO(3)(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2.3
342796992021SLC4A2 anion exchanger promotes tumour cell malignancy via enhancing net acid efflux across golgi membranes.6
349440082021Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune Scenario.5
337276332021Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)/HCO(3)(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2.3
342796992021SLC4A2 anion exchanger promotes tumour cell malignancy via enhancing net acid efflux across golgi membranes.6
349440082021Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune Scenario.5
331826432020Intracellular Ca(2+)-Mediated AE2 Is Involved in the Vectorial Movement of HaCaT Keratinocyte.8
331826432020Intracellular Ca(2+)-Mediated AE2 Is Involved in the Vectorial Movement of HaCaT Keratinocyte.8
284557482017CK2 is a key regulator of SLC4A2-mediated Cl(-)/HCO(3)(-) exchange in human airway epithelia.7
287439112017Knockdown of anion exchanger 2 suppressed the growth of ovarian cancer cells via mTOR/p70S6K1 signaling.10
284557482017CK2 is a key regulator of SLC4A2-mediated Cl(-)/HCO(3)(-) exchange in human airway epithelia.7

Citation

Dessen P

SLC4A2 (solute carrier family 4 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43994/favicon/js/web-card-_common.js