LTC4S (leukotriene C4 synthase)

2007-06-01 Affiliation

HGNC

LTC4S

LOCATION

5q35.3

LOCUSID

4056

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

dbSNP: 4056
ClinVar: 4056
TCGA: ENSG00000213316
COSMIC: LTC4S

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Arachidonic acid metabolism	KEGG	hsa00590
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)	REACTOME	R-HSA-2142691
Synthesis of 5-eicosatetraenoic acids	REACTOME	R-HSA-2142688
Synthesis of Lipoxins (LX)	REACTOME	R-HSA-2142700

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PD
PA445999	Urticaria	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	15100686, 16433794, 19862937
PA448497	aspirin	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	15100686, 16433794, 19862937
PA450546	montelukast	Chemical	ClinicalAnnotation	associated	PD

Pubmed ID	Year	Title	Citations
16293801	2006	Influence of leukotriene pathway polymorphisms on response to montelukast in asthma.	64
17632546	2007	Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.	61
17632548	2007	Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.	55
19247692	2009	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	39
17460547	2007	Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.	28
19956635	2009	Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.	27
12589355	2003	Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthma.	25
14749922	2004	Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase.	23
18323512	2008	Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.	21
19131662	2009	A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.	21

Dessen P

LTC4S (leukotriene C4 synthase)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01