TNK2 (tyrosine kinase non receptor 2)

2007-02-01  

Identity

HGNC
TNK2
LOCATION
3q29
LOCUSID
10188
ALIAS
ACK,ACK-1,ACK1,p21cdc42Hs
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10188
MIM: 606994
HGNC: 19297
Ensembl: ENSG00000061938

Variants:

dbSNP: 10188
ClinVar: 10188
TCGA: ENSG00000061938
COSMIC: TNK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000061938ENST00000333602Q07912
ENSG00000061938ENST00000381916A0A499FJ16
ENSG00000061938ENST00000428187C9J1X3
ENSG00000061938ENST00000439230Q07912

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386500112024ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.1
386500112024ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.1
367733332023Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.1
368541712023Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.0
369802412023Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.1
371337192023Host factor TNK2 is required for influenza virus infection.1
371943232023ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.1
367733332023Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.1
368541712023Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.0
369802412023Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.1
371337192023Host factor TNK2 is required for influenza virus infection.1
371943232023ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.1
354295002022Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.7
361780702022Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.3
354295002022Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.7

Citation

Dessen P

TNK2 (tyrosine kinase non receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/44030/tumors-explorer/case-report-explorer/css/card-gene.css