TNK2 (tyrosine kinase non receptor 2)

2007-02-01  

Identity

HGNC
LOCATION
3q29
LOCUSID
ALIAS
ACK,ACK-1,ACK1,p21cdc42Hs
FUSION GENES

Other Information

Locus ID:

NCBI: 10188
MIM: 606994
HGNC: 19297
Ensembl: ENSG00000061938

Variants:

dbSNP: 10188
ClinVar: 10188
TCGA: ENSG00000061938
COSMIC: TNK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000061938ENST00000333602Q07912
ENSG00000061938ENST00000381916A0A499FJ16
ENSG00000061938ENST00000428187C9J1X3
ENSG00000061938ENST00000439230Q07912

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386500112024ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.1
386500112024ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.1
367733332023Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.1
368541712023Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.0
369802412023Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.1
371337192023Host factor TNK2 is required for influenza virus infection.1
371943232023ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.1
367733332023Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.1
368541712023Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.0
369802412023Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.1
371337192023Host factor TNK2 is required for influenza virus infection.1
371943232023ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.1
354295002022Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.7
361780702022Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.3
354295002022Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.7

Citation

Dessen P

TNK2 (tyrosine kinase non receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/44030/tumors-explorer/case-report-explorer/js/lib/zoomerang.js