FSCN1 (fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus))

2008-11-01 Shoichi Nagai , Christian A Smith , Soma Mondal , James T Rutka Affiliation

The Arthur, Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Identity

HGNC

FSCN1

LOCATION

7p22.1

LOCUSID

6624

ALIAS

FAN1,HSN,SNL,p55

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

The gene encompasses 13,833 bp of DNA.

Transcription

The length of the transcript is 2,819 bp containing 1,482 bp open reading frame.

Proteins

Description

FSCN1 encodes a 493-amino acid protein fascin with a molecular mass of 55 kD. Fascin was first isolated from sea urchin egg extracts, and then identified in Drosophila and in B-lymphocytes.

Expression

Fascin is widely expressed including the brain, blood, colon, lung, breast, ovary, and testis. In the brain, fascin expression has been localized to neurons, glial cells, and endothelial cells.

Localisation

Fascin colocalizes with filopodia, membrane ruffles, lamellopodia, microspikes, focal adhesions, cytoplasm and actin stress fibers. Additionally, fascin has been shown to localize to lamellipodia and filopodia in growth cones of cultured neurons.

Function

Fascin is an actin-bundling protein that provides rigidity to filopodial bundles to efficiently push the membrane forward during cytoskeleton remodeling and cell migration.

Mutations

Germinal

unknown

Somatic

unknown

Implicated in

Entity name

Glioma

Disease

Fascin expression increases with increasing histological grade of glioma and is associated with adhesion, migration, and invasion of glioma cells.

Entity name

Cancer

Disease

High-level expression of fascin has been observed in several types of human neoplasms, such as cancer of colon, breast, lung, kidney, ovary, cervix, and esophagus. It correlates with lymph node or distant metastasis in cancers of colon, kidney, and esophagus, and plays a role as an independent marker of poor prognosis. It is also associated with increased cellular proliferation in non-small cell lung adenocarcinoma, colon carcinoma, and esophageal squamous cell carcinoma. In colon adenocarcinoma and esophageal carcinoma cells, fascin is associated with cellular motility and invasive properties.

Bibliography

Pubmed ID	Last Year	Title	Authors
17650213	2007	Expression of fascin in oral and oropharyngeal squamous cell carcinomas has prognostic significance - a tissue microarray study of 129 cases.	Chen SF et al
11039904	2000	C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines.	Grothey A et al
17029629	2006	Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas.	Hashimoto Y et al
18283337	2008	The role of fascin in the migration and invasiveness of malignant glioma cells.	Hwang JH et al
12507891	2003	Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro.	Jawhari AU et al
16620052	2006	Actin bundling protein fascin expression in ovarian neoplasms: comparison of histopathologic features of tumors obtained by the first and secondary cytoreduction surgeries.	Kabukcuoglu S et al
12592367	2003	Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer.	Pelosi G et al
14756441	2003	Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades.	Peraud A et al
17375048	2007	Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma.	Puppa G et al
16308158	2005	Fascin expression in 90 patients with glioblastoma multiforme.	Roma AA et al
16185662	2005	Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells.	Xie JJ et al
16524962	2006	Fascin is a potential biomarker for early-stage oesophageal squamous cell carcinoma.	Zhang H et al
16979727	2006	Biologic significance of fascin expression in clear cell renal cell carcinoma: systematic analysis of primary and metastatic tumor tissues using a tissue microarray technique.	Zigeuner R et al

Other Information

Locus ID:

NCBI: 6624
MIM: 602689
HGNC: 11148
Ensembl: ENSG00000075618

Variants:

dbSNP: 6624
ClinVar: 6624
TCGA: ENSG00000075618
COSMIC: FSCN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000075618	ENST00000382361	Q16658
ENSG00000075618	ENST00000382361	A0A384MEG1
ENSG00000075618	ENST00000405801	A0A0A0MSB2
ENSG00000075618	ENST00000444748	C9JFC0
ENSG00000075618	ENST00000447103	C9JPH9

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20137952	2010	The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion.	106
17638895	2007	Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer.	90
16533778	2006	Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas.	81
18599451	2008	A myosin motor that selects bundled actin for motility.	70
15671545	2005	The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course.	61
19729655	2009	Rab35 controls actin bundling by recruiting fascin as an effector protein.	56
17029629	2006	Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas.	47
21258769	2011	Restoration of miR-145 expression suppresses cell proliferation, migration and invasion in prostate cancer by targeting FSCN1.	47
12592367	2003	Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer.	46
19818782	2010	Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression.	45

Citation

Shoichi Nagai ; Christian A Smith ; Soma Mondal ; James T Rutka

FSCN1 (fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus))

Atlas Genet Cytogenet Oncol Haematol. 2008-11-01

Online version: http://atlasgeneticsoncology.org/gene/44342/fscn1-(fascin-homolog-1-actin-bundling-protein-(strongylocentrotus-purpuratus))