PIAS4 (protein inhibitor of activated STAT 4)

2007-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
PIAS-gamma,PIASY,Piasg,ZMIZ6
FUSION GENES

Other Information

Locus ID:

NCBI: 51588
MIM: 605989
HGNC: 17002
Ensembl: ENSG00000105229

Variants:

dbSNP: 51588
ClinVar: 51588
TCGA: ENSG00000105229
COSMIC: PIAS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105229ENST00000262971Q8N2W9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Jak-STAT signaling pathwayKEGGko04630
Ubiquitin mediated proteolysisKEGGhsa04120
Jak-STAT signaling pathwayKEGGhsa04630
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571
SUMOylation of transcription factorsREACTOMER-HSA-3232118
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169061472006PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.81
167935472006The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis.72
125115582003A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.50
173532732007PIASy-mediated sumoylation of Yin Yang 1 depends on their interaction but not the RING finger.38
237042802013A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.37
168163902006The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.35
171836832006PIASgamma is required for faithful chromosome segregation in human cells.35
128150422003Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3.30
149815442004PIASy-mediated repression of the androgen receptor is independent of sumoylation.28
203005312010Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification.28

Citation

Dessen P

PIAS4 (protein inhibitor of activated STAT 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45557/pias4