NCR1 (natural cytotoxicity triggering receptor 1)

2007-02-01  

Identity

HGNC
NCR1
LOCATION
19q13.42
LOCUSID
9437
ALIAS
CD335,LY94,NK-p46,NKP46
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9437
MIM: 604530
HGNC: 6731
Ensembl: ENSG00000189430

Variants:

dbSNP: 9437
ClinVar: 9437
TCGA: ENSG00000189430
COSMIC: NCR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189430ENST00000291890A0A0A0MQZ0
ENSG00000189430ENST00000338835A0A0A0MR94
ENSG00000189430ENST00000350790O76036
ENSG00000189430ENST00000357397O76036
ENSG00000189430ENST00000594765A0A0A0MTU0
ENSG00000189430ENST00000598576M0QYD1

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
370200262023The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells.26
370200262023The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells.26
333688322021Expression of natural cytotoxicity receptor NKp46 on peripheral blood natural killer cells in women with a history of recurrent implantation failures.5
339306662021Co-expression of NKp46 with activating or inhibitory receptors on, and cytokine production by, uterine endometrial NK cells in recurrent pregnancy loss.7
344649052021NK cells that differ in expression of NKp46 might play different roles in endometrium.4
333688322021Expression of natural cytotoxicity receptor NKp46 on peripheral blood natural killer cells in women with a history of recurrent implantation failures.5
339306662021Co-expression of NKp46 with activating or inhibitory receptors on, and cytokine production by, uterine endometrial NK cells in recurrent pregnancy loss.7
344649052021NK cells that differ in expression of NKp46 might play different roles in endometrium.4
319895892020Low-dose IL-2 induces CD56(bright) NK regulation of T cells via NKp44 and NKp46.7
319895892020Low-dose IL-2 induces CD56(bright) NK regulation of T cells via NKp44 and NKp46.7
304487722019NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: a CELAC study.20
311323152019STAT3 directly regulates NKp46 transcription in NK cells of HBeAg-negative CHB patients.16
311340552019The Natural Cytotoxicity Receptors in Health and Disease.179
311552322019Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity.200
304487722019NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: a CELAC study.20

Citation

Dessen P

NCR1 (natural cytotoxicity triggering receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45588/js/lib/js/lib/all.min.js