CISH (cytokine inducible SH2 containing protein)

2007-02-01  

Identity

HGNC
CISH
LOCATION
3p21.2
LOCUSID
1154
ALIAS
BACTS2,CIS,CIS-1,G18,SOCS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1154
MIM: 602441
HGNC: 1984
Ensembl: ENSG00000114737

Variants:

dbSNP: 1154
ClinVar: 1154
TCGA: ENSG00000114737
COSMIC: CISH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114737ENST00000348721Q9NSE2
ENSG00000114737ENST00000443053Q9NSE2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
ECS complexKEGGhsa_M00388
ECS complexKEGGM00388
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
JAK-STAT signalingKEGGhsa_M00684
JAK-STAT signalingKEGGM00684
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Growth hormone receptor signalingREACTOMER-HSA-982772

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371185542023CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging.6
375636922023CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma.5
371185542023CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging.6
375636922023CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma.5
340726012021Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer.10
340726012021Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer.10
320974622020NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.45
329614832020MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking.20
320974622020NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.45
329614832020MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking.20
301971852019CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts.8
301971852019CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts.8
293254542018Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis.18
295932272018The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8(+) T cells.14
299206552018Genetic contribution of suppressor of cytokine signalling polymorphisms to the susceptibility to infection after traumatic injury.3

Citation

Dessen P

CISH (cytokine inducible SH2 containing protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45611/img/favicon/favicon-32x32.png