EIF4G2 (eukaryotic translation initiation factor 4 gamma 2)

2007-02-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
AAG1,DAP5,NAT1,P97
FUSION GENES

Other Information

Locus ID:

NCBI: 1982
MIM: 602325
HGNC: 3297
Ensembl: ENSG00000110321

Variants:

dbSNP: 1982
ClinVar: 1982
TCGA: ENSG00000110321
COSMIC: EIF4G2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110321ENST00000339995D3DQV9
ENSG00000110321ENST00000396525H0Y3P2
ENSG00000110321ENST00000524932H0YEC5
ENSG00000110321ENST00000525681D3DQV9
ENSG00000110321ENST00000526148D3DQV9
ENSG00000110321ENST00000527419H0YE44
ENSG00000110321ENST00000527526H0YEN8
ENSG00000110321ENST00000528562H0YE87
ENSG00000110321ENST00000528839H0YE22
ENSG00000110321ENST00000530211H0YDC0
ENSG00000110321ENST00000530702H0YEI7
ENSG00000110321ENST00000531180E9PKF8
ENSG00000110321ENST00000531416H0YCH5
ENSG00000110321ENST00000531647H0YD99
ENSG00000110321ENST00000532082H0YD77
ENSG00000110321ENST00000532570H0YCF8
ENSG00000110321ENST00000534605H0YEW3

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Viral myocarditisKEGGhsa05416
RNA transportKEGGko03013
RNA transportKEGGhsa03013
eIF4F complexKEGGhsa_M00428
eIF4F complexKEGGM00428
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
90493101997A new translational regulator with homology to eukaryotic translation initiation factor 4G.70
184504932008DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis.62
113315972001Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.52
119438662002The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins.52
171950952007Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1.44
150168482004Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.35
169327492006p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins.31
257790442015DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation.27
233184442014The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA.23
157181032005Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2).21

Citation

Dessen P

EIF4G2 (eukaryotic translation initiation factor 4 gamma 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45619/eif4g2