PELP1 (proline, glutamate and leucine rich protein 1)

2007-02-01  

Identity

HGNC
PELP1
LOCATION
17p13.2
LOCUSID
27043
ALIAS
MNAR,P160
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27043
MIM: 609455
HGNC: 30134
Ensembl: ENSG00000141456

Variants:

dbSNP: 27043
ClinVar: 27043
TCGA: ENSG00000141456
COSMIC: PELP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141456ENST00000301396C9JFV4
ENSG00000141456ENST00000436683E7EV54
ENSG00000141456ENST00000570387I3L4P1
ENSG00000141456ENST00000570571I3L445
ENSG00000141456ENST00000572293Q8IZL8
ENSG00000141456ENST00000572293C9JFV4
ENSG00000141456ENST00000574876Q8IZL8
ENSG00000141456ENST00000575101I3L1P4
ENSG00000141456ENST00000575329I3L4M7

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Gene ExpressionREACTOMER-HSA-74160
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 ExpressionREACTOMER-HSA-8849473
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365778842023Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality.1
371599182023PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis.0
365778842023Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality.1
371599182023PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis.0
359699402022PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug.2
359699402022PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug.2
332695402021Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling.14
336075892021PELP1 promotes the expression of RUNX2 via the ERK pathway during the osteogenic differentiation of human periodontal ligament stem cells.0
341036812021PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer.13
342575302021Overexpression of PELP1 in Lung Adenocarcinoma Promoted E(2) Induced Proliferation, Migration and Invasion of the Tumor Cells and Predicted a Worse Outcome of the Patients.3
332695402021Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling.14
336075892021PELP1 promotes the expression of RUNX2 via the ERK pathway during the osteogenic differentiation of human periodontal ligament stem cells.0
341036812021PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer.13
342575302021Overexpression of PELP1 in Lung Adenocarcinoma Promoted E(2) Induced Proliferation, Migration and Invasion of the Tumor Cells and Predicted a Worse Outcome of the Patients.3
320374842020Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells.7

Citation

Dessen P

PELP1 (proline, glutamate and leucine rich protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45632/css/css/lib/bootstrap.min.css