KRT5 (keratin 5)

2007-02-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
CK5,DDD,DDD1,EBS2,K5,KRT5A
FUSION GENES

Other Information

Locus ID:

NCBI: 3852
MIM: 148040
HGNC: 6442
Ensembl: ENSG00000186081

Variants:

dbSNP: 3852
ClinVar: 3852
TCGA: ENSG00000186081
COSMIC: KRT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186081ENST00000252242P13647
ENSG00000186081ENST00000546577F8VV57
ENSG00000186081ENST00000548409H0YI76
ENSG00000186081ENST00000549420F8W0C6
ENSG00000186081ENST00000551188H0YIN9
ENSG00000186081ENST00000551275F8VU69

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195783632009New common variants affecting susceptibility to basal cell carcinoma.135
124661142002Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome.134
176503142007Use of immunohistochemical markers can refine prognosis in triple negative breast cancer.112
197209112009Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel.79
194619982009An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate.72
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
219005002011Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells.62
227511192013Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4.57
211642832011Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6.53
206651032011Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopulation in luminal breast cancers.48

Citation

Dessen P

KRT5 (keratin 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45642/krt5-(keratin-5)