KRT5 (keratin 5)

2007-02-01  

Identity

HGNC
KRT5
LOCATION
12q13.13
LOCUSID
3852
ALIAS
CK5,DDD,DDD1,EBS2,K5,KRT5A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3852
MIM: 148040
HGNC: 6442
Ensembl: ENSG00000186081

Variants:

dbSNP: 3852
ClinVar: 3852
TCGA: ENSG00000186081
COSMIC: KRT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186081ENST00000252242P13647
ENSG00000186081ENST00000546577F8VV57
ENSG00000186081ENST00000548409H0YI76
ENSG00000186081ENST00000549420F8W0C6
ENSG00000186081ENST00000551188H0YIN9
ENSG00000186081ENST00000551275F8VU69

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362395612023Clinicopathological features of cytokeratin 5-positive pulmonary adenocarcinoma.1
368095732023KRT5 mutation regulate melanin metabolism through notch signalling pathway between keratinocytes and melanocytes.2
372126982023Keratin 5 in Lung Cancer Specimens: Comparison of Four Antibody Clones and KRT5 mRNA-ISH.0
377587002023Lung extracellular matrix modulates KRT5(+) basal cell activity in pulmonary fibrosis.4
362395612023Clinicopathological features of cytokeratin 5-positive pulmonary adenocarcinoma.1
368095732023KRT5 mutation regulate melanin metabolism through notch signalling pathway between keratinocytes and melanocytes.2
372126982023Keratin 5 in Lung Cancer Specimens: Comparison of Four Antibody Clones and KRT5 mRNA-ISH.0
377587002023Lung extracellular matrix modulates KRT5(+) basal cell activity in pulmonary fibrosis.4
355270472022Cytokeratin 5/6 expression in pT1 bladder cancer predicts intravesical recurrence in patients treated with bacillus Calmette-Guérin instillation.0
356394592022Cytokeratins 5 and 17 Maintain an Aggressive Epithelial State in Basal-Like Breast Cancer.2
355270472022Cytokeratin 5/6 expression in pT1 bladder cancer predicts intravesical recurrence in patients treated with bacillus Calmette-Guérin instillation.0
356394592022Cytokeratins 5 and 17 Maintain an Aggressive Epithelial State in Basal-Like Breast Cancer.2
329898622021Severe skin fragility with postnatal lethal outcome due to a biallelic KRT5 mutation.0
334351732021Comprehensive Gene Expression Analyses of Immunohistochemically Defined Subgroups of Muscle-Invasive Urinary Bladder Urothelial Carcinoma.7
345091712021Molecular origin of the effects of mutation on the structure and mechanical properties of human epithelial keratin K5/K14.1

Citation

Dessen P

KRT5 (keratin 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45642/meetings/js/lib/favicon/img/logo-atlas-4.svg