FUCA1 (alpha-L-fucosidase 1)

2007-02-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
FUCA
FUSION GENES

Other Information

Locus ID:

NCBI: 2517
MIM: 612280
HGNC: 4006
Ensembl: ENSG00000179163

Variants:

dbSNP: 2517
ClinVar: 2517
TCGA: ENSG00000179163
COSMIC: FUCA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179163ENST00000374479P04066

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Other glycan degradationKEGGko00511
Other glycan degradationKEGGhsa00511
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
Reactions specific to the complex N-glycan synthesis pathwayREACTOMER-HSA-975578
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
269987412016Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells.14
245694612014Alpha-1-fucosidase as a prognostic indicator for hepatocellular carcinoma following hepatectomy: a large-scale, long-term study.13
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
273151692016p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death.8
190645722008Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.7
251294432014Evaluation of squamous cell carcinoma antigen-immunoglobulin M complex (SCCA-IGM) and alpha-L-fucosidase (AFU) as novel diagnostic biomarkers for hepatocellular carcinoma.6
284049182017Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer.6
182174162007Activity of lysosomal exoglycosidases in saliva of patients with HIV infection.5
284404162017FUCA1 is induced by wild-type p53 and expressed at different levels in thyroid cancers depending on p53 status.4
295182792018Transcriptomic analysis of FUCA1 knock-down in keratinocytes reveals new insights into the pathogenesis of fucosidosis skin lesions.3

Citation

Dessen P

FUCA1 (alpha-L-fucosidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45671/fuca1-(alpha-l-fucosidase-1)