IGFBP5 (insulin like growth factor binding protein 5)

2007-02-01  

Identity

HGNC
IGFBP5
LOCATION
2q35
LOCUSID
3488
ALIAS
IBP5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3488
MIM: 146734
HGNC: 5474
Ensembl: ENSG00000115461

Variants:

dbSNP: 3488
ClinVar: 3488
TCGA: ENSG00000115461
COSMIC: IGFBP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115461ENST00000233813P24593
ENSG00000115461ENST00000233813A0A024R433
ENSG00000115461ENST00000449583C9JXX4

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426

References

Pubmed IDYearTitleCitations
381593632024Secreted insulin-like growth factor binding protein 5 functions as a tumor suppressor and chemosensitizer through inhibiting insulin-like growth factor 1 receptor/protein kinase B pathway in acute myeloid leukemia.0
383181922024Transcriptional profile of human thymus reveals IGFBP5 is correlated with age-related thymic involution.0
383510102024IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors.3
388747072024Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract.0
388869002024Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis.1
381593632024Secreted insulin-like growth factor binding protein 5 functions as a tumor suppressor and chemosensitizer through inhibiting insulin-like growth factor 1 receptor/protein kinase B pathway in acute myeloid leukemia.0
383181922024Transcriptional profile of human thymus reveals IGFBP5 is correlated with age-related thymic involution.0
383510102024IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors.3
388747072024Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract.0
388869002024Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis.1
369183352023Circ_0008450 regulates keloid-derived fibroblast proliferation, migration, invasion and apoptosis with increased IGFBP5 through sponging miR-1224-5p.0
369490682023IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.3
369183352023Circ_0008450 regulates keloid-derived fibroblast proliferation, migration, invasion and apoptosis with increased IGFBP5 through sponging miR-1224-5p.0
369490682023IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.3
348221332022Overexpression of long noncoding RNA MCM3AP-AS1 promotes osteogenic differentiation of dental pulp stem cells via miR-143-3p/IGFBP5 axis.4

Citation

Dessen P

IGFBP5 (insulin like growth factor binding protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45717/css/img/logo-atlas-4.svg