GPR4 (G protein-coupled receptor 4)

2007-02-01  

Identity

HGNC
GPR4
LOCATION
19q13.32
LOCUSID
2828
ALIAS
GPR6C.l

Other Information

Locus ID:

NCBI: 2828
MIM: 600551
HGNC: 4497
Ensembl: ENSG00000177464

Variants:

dbSNP: 2828
ClinVar: 2828
TCGA: ENSG00000177464
COSMIC: GPR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177464ENST00000323040P46093

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384108652024Acid-sensing receptor GPR4 plays a crucial role in lymphatic cancer metastasis.1
385270542024The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.0
384108652024Acid-sensing receptor GPR4 plays a crucial role in lymphatic cancer metastasis.1
385270542024The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.0
365625562023GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment.4
365625562023GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment.4
331611352021Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway.8
334789382021The evolution and mechanism of GPCR proton sensing.23
331611352021Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway.8
334789382021The evolution and mechanism of GPCR proton sensing.23
323704922020Antagonism of GPR4 with NE 52-QQ57 and the Suppression of AGE-Induced Degradation of Type II Collagen in Human Chondrocytes.6
329487832020Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.9
323704922020Antagonism of GPR4 with NE 52-QQ57 and the Suppression of AGE-Induced Degradation of Type II Collagen in Human Chondrocytes.6
329487832020Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.9
315305022019Increased proton-sensing receptor GPR4 signalling promotes colorectal cancer progression by activating the hippo pathway.21

Citation

Dessen P

GPR4 (G protein-coupled receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45722/deep-insight-explorer/js/lib/jquery-3.5.1.min.js