ADI1 (acireductone dioxygenase 1)

2007-02-01  

Identity

HGNC
ADI1
LOCATION
2p25.3
LOCUSID
55256
ALIAS
APL1,ARD,Fe-ARD,HMFT1638,MTCBP1,Ni-ARD,SIPL,mtnD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55256
MIM: 613400
HGNC: 30576
Ensembl: ENSG00000182551

Variants:

dbSNP: 55256
ClinVar: 55256
TCGA: ENSG00000182551
COSMIC: ADI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182551ENST00000327435Q9BV57
ENSG00000182551ENST00000382093Q9BV57
ENSG00000182551ENST00000415131H7C382

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Methionine salvage pathwayKEGGhsa_M00034
Methionine salvage pathwayKEGGM00034
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Methionine salvage pathwayREACTOMER-HSA-1237112
Sulfur amino acid metabolismREACTOMER-HSA-1614635

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
324800402020Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.7
324800402020Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.7
304871812019Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1.23
304871812019Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1.23
300669002018Enolase-phosphatase 1 as a novel potential malignant glioma indicator promotes cell proliferation and migration.6
300669002018Enolase-phosphatase 1 as a novel potential malignant glioma indicator promotes cell proliferation and migration.6
280626482017Dual chemistry catalyzed by human acireductone dioxygenase.7
280626482017Dual chemistry catalyzed by human acireductone dioxygenase.7
256409482016Evidence of MTCBP-1 interaction with the cytoplasmic domain of MT1-MMP: Implications in the autophagy cell index of high-grade glioblastoma.16
265370612016Interaction between hepatic membrane type 1 matrix metalloproteinase and acireductone dioxygenase 1 regulates hepatitis C virus infection.7
256409482016Evidence of MTCBP-1 interaction with the cytoplasmic domain of MT1-MMP: Implications in the autophagy cell index of high-grade glioblastoma.16
265370612016Interaction between hepatic membrane type 1 matrix metalloproteinase and acireductone dioxygenase 1 regulates hepatitis C virus infection.7
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
196266142009293 cells over-expressing human ADI1 and CD81 are permissive for serum-derived hepatitis C virus infection.6

Citation

Dessen P

ADI1 (acireductone dioxygenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45729/gene-fusions/gene-fusions/css/lib/dataTables.bootstrap.min.css