NR2C1 (nuclear receptor subfamily 2 group C member 1)

2007-02-01  

Identity

HGNC
NR2C1
LOCATION
12q22
LOCUSID
7181
ALIAS
TR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7181
MIM: 601529
HGNC: 7971
Ensembl: ENSG00000120798

Variants:

dbSNP: 7181
ClinVar: 7181
TCGA: ENSG00000120798
COSMIC: NR2C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120798ENST00000330677P13056
ENSG00000120798ENST00000333003P13056
ENSG00000120798ENST00000333003H9NIM2
ENSG00000120798ENST00000393101P13056
ENSG00000120798ENST00000393101H9NIM3
ENSG00000120798ENST00000547469F8W1Q1
ENSG00000120798ENST00000551647H0YIV1
ENSG00000120798ENST00000552791H0YHC6
ENSG00000120798ENST00000622476A0A087WUK4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
120937442002An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.55
120938042002Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor.15
129499362003TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3.6
126153662003Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.1
170109342006Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A.1

Citation

Dessen P

NR2C1 (nuclear receptor subfamily 2 group C member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45733/nr2c1