ZEB2 (zinc finger E-box binding homeobox 2)

2007-02-01  

Identity

HGNC
LOCATION
2q22.3
LOCUSID
ALIAS
HSPC082,SIP-1,SIP1,SMADIP1,ZFHX1B
FUSION GENES

Other Information

Locus ID:

NCBI: 9839
MIM: 605802
HGNC: 14881
Ensembl: ENSG00000169554

Variants:

dbSNP: 9839
ClinVar: 9839
TCGA: ENSG00000169554
COSMIC: ZEB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169554ENST00000303660A0JP08
ENSG00000169554ENST00000392861E7ESP8
ENSG00000169554ENST00000409211E7EVG9
ENSG00000169554ENST00000409487O60315
ENSG00000169554ENST00000419938H7C0G0
ENSG00000169554ENST00000427902E7EUW9
ENSG00000169554ENST00000431672U3KPV5
ENSG00000169554ENST00000434448A0A0D9SG93
ENSG00000169554ENST00000435831C9JU62
ENSG00000169554ENST00000440875U3KQ51
ENSG00000169554ENST00000444559C9JUQ1
ENSG00000169554ENST00000462355U3KQ33
ENSG00000169554ENST00000465070U3KQ33
ENSG00000169554ENST00000465308A0A0D9SGG5
ENSG00000169554ENST00000470879U3KPX6
ENSG00000169554ENST00000484313A0A0D9SF71
ENSG00000169554ENST00000539609O60315
ENSG00000169554ENST00000558170O60315
ENSG00000169554ENST00000627532O60315
ENSG00000169554ENST00000629520U3KQ33
ENSG00000169554ENST00000630572A0A0D9SF74
ENSG00000169554ENST00000636026A0A1B0GW50
ENSG00000169554ENST00000636413A0A1B0GVV8
ENSG00000169554ENST00000636445A0A1B0GWA7
ENSG00000169554ENST00000636471A0A1B0GV02
ENSG00000169554ENST00000636732A0A1B0GUM8
ENSG00000169554ENST00000637045A0A1B0GVV8
ENSG00000169554ENST00000637267A0A1X7SC99
ENSG00000169554ENST00000637304A0A1B0GVV8
ENSG00000169554ENST00000637873A0A1B0GTH3
ENSG00000169554ENST00000638007A0A1B0GVV8
ENSG00000169554ENST00000638087A0A1B0GVV8
ENSG00000169554ENST00000638128A0A1B0GWI0
ENSG00000169554ENST00000639389A0A1W2PS25
ENSG00000169554ENST00000647488A0A2R8YDQ8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183763962008The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.1525
184112772008The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.658
114308292001The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.451
188295402008A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition.446
214116262011An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.217
215187992011p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.213
205856272010Web-based, participant-driven studies yield novel genetic associations for common traits.155
121614432002Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.150
127430392003Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.129
157423342005Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma.129

Citation

Dessen P

ZEB2 (zinc finger E-box binding homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45746/zeb2-(zinc-finger-e-box-binding-homeobox-2)