DCX (doublecortin)

2007-02-01  

Identity

HGNC
DCX
LOCATION
Xq23
LOCUSID
1641
ALIAS
DBCN,DC,LISX,SCLH,XLIS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1641
MIM: 300121
HGNC: 2714
Ensembl: ENSG00000077279

Variants:

dbSNP: 1641
ClinVar: 1641
TCGA: ENSG00000077279
COSMIC: DCX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077279ENST00000356220A8K340
ENSG00000077279ENST00000358070O43602
ENSG00000077279ENST00000371993O43602
ENSG00000077279ENST00000468911E7EU50
ENSG00000077279ENST00000488120O43602
ENSG00000077279ENST00000496551O43602
ENSG00000077279ENST00000635795O43602
ENSG00000077279ENST00000636035A8K340
ENSG00000077279ENST00000636381A0A1B0GUE1
ENSG00000077279ENST00000637453A8K340
ENSG00000077279ENST00000637570A0A1B0GWD1

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Neurofascin interactionsREACTOMER-HSA-447043

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352130592022Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics.4
352130592022Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics.4
320509722020Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.7
320509722020Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.7
304439882019Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR-488-3p in Hirschsprung's disease.16
306253472019Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments.4
309795002019Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association.0
304439882019Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR-488-3p in Hirschsprung's disease.16
306253472019Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments.4
309795002019Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association.0
302911442018A dominant dendrite phenotype caused by the disease-associated G253D mutation in doublecortin (DCX) is not due to its endocytosis defect.3
302911442018A dominant dendrite phenotype caused by the disease-associated G253D mutation in doublecortin (DCX) is not due to its endocytosis defect.3
287017242017Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus.8
287669052017Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers.60
287017242017Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus.8

Citation

Dessen P

DCX (doublecortin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45751/img/js/lib/popper.js