DICER1 (dicer 1, ribonuclease III)

2007-02-01  

Identity

HGNC
DICER1
LOCATION
14q32.13
LOCUSID
23405
ALIAS
DCR1,Dicer,Dicer1e,GLOW,HERNA,K12H4.8-LIKE,MNG1,RMSE2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23405
MIM: 606241
HGNC: 17098
Ensembl: ENSG00000100697

Variants:

dbSNP: 23405
ClinVar: 23405
TCGA: ENSG00000100697
COSMIC: DICER1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100697ENST00000343455Q9UPY3
ENSG00000100697ENST00000393063Q9UPY3
ENSG00000100697ENST00000526495Q9UPY3
ENSG00000100697ENST00000527414Q9UPY3
ENSG00000100697ENST00000529720Q5D0K5
ENSG00000100697ENST00000531162Q5D0K5
ENSG00000100697ENST00000532939H0YJZ6
ENSG00000100697ENST00000541352Q9UPY3
ENSG00000100697ENST00000556045Q9UPY3
ENSG00000100697ENST00000556045A0A076VAC5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927
Small interfering RNA (siRNA) biogenesisREACTOMER-HSA-426486

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378674152024USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression.1
379896462024No Pathogenic DICER1 Gene Variants in a Cohort Study of 28 Children With Congenital Pulmonary Airway Malformation.0
380503712024Fetal Type Morphologies Suggest the Presence of DICER1 Hotspot Mutations in Non-small Cell Lung Cancer.0
381677212024Two-motif model illuminates DICER cleavage preferences.0
381954232024DiCleave: a deep learning model for predicting human Dicer cleavage sites.0
382528732024Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.3
382611142024Substrate promiscuity of Dicer toward precursors of the let-7 family and their 3'-end modifications.0
382804762024Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.0
383302932024Prevalence of DICER1 variants in large multinodular goiter: thyroid function, clinical and imaging characteristics.0
383579122024Pathogenic Somatic Mutation of DICER1 and Clinicopathological Features in Nasal Chondromesenchymal Hamartomas: A Series of Nine Cases.0
385087192024Prevalence of lung cysts in adolescents and adults with a germline DICER1 pathogenic/likely pathogenic variant: a report from the National Institutes of Health and International Pleuropulmonary Blastoma/DICER1 Registry.0
385202192024Comprehensive evaluation of cytomorphologic, histologic, and molecular features of DICER1-altered thyroid lesions on FNA: A multipractice experience.1
385583292024Thyroid nodules with DICER1 mutation or PTEN alteration: A comparative cytologic, clinical, and molecular study of 117 FNA cases.0
385708822024Clinicopathological analysis of 22 Müllerian adenosarcomas and the sequencing of DICER1 mutation.0
387423502024[The clinicopathological features of adult thyroid tumors with DICER1 mutation].0

Citation

Dessen P

DICER1 (dicer 1, ribonuclease III)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45773/img/tumors-explorer/js/web-card-_common.js