CCK (cholecystokinin)

2007-02-01  

Identity

HGNC
LOCATION
3p22.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 885
MIM: 118440
HGNC: 1569
Ensembl: ENSG00000187094

Variants:

dbSNP: 885
ClinVar: 885
TCGA: ENSG00000187094
COSMIC: CCK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187094ENST00000334681P06307
ENSG00000187094ENST00000334681Q6FG82
ENSG00000187094ENST00000396169P06307
ENSG00000187094ENST00000396169Q6FG82
ENSG00000187094ENST00000434608P06307
ENSG00000187094ENST00000434608Q6FG82

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
197411172009Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent.80
230640142012A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.77
185558022008Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells.42
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
235644492013Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis.34
129200592003Cholecystokinin and stomach distension combine to reduce food intake in humans.31
174381022007Cholecystokinin down-regulation by RNA interference impairs Ewing tumor growth.30
204680642010Association study of 182 candidate genes in anorexia nervosa.30

Citation

Dessen P

CCK (cholecystokinin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45801/cck-(cholecystokinin)