PVR (PVR cell adhesion molecule)

2007-02-01  

Identity

HGNC
PVR
LOCATION
19q13.31
LOCUSID
5817
ALIAS
CD155,HVED,NECL5,Necl-5,PVS,TAGE4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5817
MIM: 173850
HGNC: 9705
Ensembl: ENSG00000073008

Variants:

dbSNP: 5817
ClinVar: 5817
TCGA: ENSG00000073008
COSMIC: PVR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073008ENST00000187830F8W7D4
ENSG00000073008ENST00000344956P15151
ENSG00000073008ENST00000403059P15151
ENSG00000073008ENST00000406449A0A0A0MSA9
ENSG00000073008ENST00000425690A0A0C4DG49
ENSG00000073008ENST00000587785K7EMC6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Nectin/Necl trans heterodimerizationREACTOMER-HSA-420597

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381761702024ADAR-mediated RNA editing regulates PVR immune checkpoint in colorectal cancer.0
382169492024The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling.0
382897062024Essential role of CD155 glycosylation in functional binding to DNAM-1 on natural killer cells.0
382914702024PITPNC1 Suppress CD8(+) T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.1
385922132024Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.0
386043262024sCD155 as a potential marker for diagnosing the vascular invasion in hepatic alveolar echinococcosis.0
381761702024ADAR-mediated RNA editing regulates PVR immune checkpoint in colorectal cancer.0
382169492024The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling.0
382897062024Essential role of CD155 glycosylation in functional binding to DNAM-1 on natural killer cells.0
382914702024PITPNC1 Suppress CD8(+) T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.1
385922132024Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.0
386043262024sCD155 as a potential marker for diagnosing the vascular invasion in hepatic alveolar echinococcosis.0
366309132023T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.13
370757052023Deficiency of the CD155-CD96 immune checkpoint controls IL-9 production in giant cell arteritis.5
373832342023Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma.2

Citation

Dessen P

PVR (PVR cell adhesion molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45814/js/lib/favicon/apple-touch-icon.png