ITPKA (inositol-trisphosphate 3-kinase A)

2007-02-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
IP3-3KA,IP3KA
FUSION GENES

Other Information

Locus ID:

NCBI: 3706
MIM: 147521
HGNC: 6178
Ensembl: ENSG00000137825

Variants:

dbSNP: 3706
ClinVar: 3706
TCGA: ENSG00000137825
COSMIC: ITPKA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137825ENST00000260386P23677
ENSG00000137825ENST00000425927C9JC74

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Calcium signaling pathwayKEGGko04020
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Calcium signaling pathwayKEGGhsa04020
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGhsa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGM00130
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP3 and IP4 in the cytosolREACTOMER-HSA-1855204

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
153502142004Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.38
200229632010Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.15
127478032003The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.13
272346022016ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.12
165256362006Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma.11
184982542008Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.11
217928812011Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.8
251019012014A new calmodulin-binding motif for inositol 1,4,5-trisphosphate 3-kinase regulation.2
262490312015ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.2
304667862019PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3.0

Citation

Dessen P

ITPKA (inositol-trisphosphate 3-kinase A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45875/itpka-(inositol-trisphosphate-3-kinase-a)