IFNL2 (interferon lambda 2)

2007-02-01  

Identity

HGNC
IFNL2
LOCATION
19q13.2
LOCUSID
282616
ALIAS
IFNL2a,IFNL3a,IL-28A,IL28A

Other Information

Locus ID:

NCBI: 282616
MIM: 607401
HGNC: 18364
Ensembl: ENSG00000183709

Variants:

dbSNP: 282616
ClinVar: 282616
TCGA: ENSG00000183709
COSMIC: IFNL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183709ENST00000331982Q8IZJ0

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
353619132022Serum IL-28A/IFN-λ2 is linked to disease severity of COVID-19.7
358169262022Assessment of serum interleukin-28 as a biomarker to predict mortality in traumatic patients with sepsis.3
363368882022Lower level of IL-28A as a predictive index of the artificial liver support system in effective treatment of patients with HBV-ACLF.2
353619132022Serum IL-28A/IFN-λ2 is linked to disease severity of COVID-19.7
358169262022Assessment of serum interleukin-28 as a biomarker to predict mortality in traumatic patients with sepsis.3
363368882022Lower level of IL-28A as a predictive index of the artificial liver support system in effective treatment of patients with HBV-ACLF.2
325572592021Interleukin-29 and interleukin-28A induce migration of neutrophils in rheumatoid arthritis.3
338853372021Linkage of Lambda Interferons in Protection Against Severe COVID-19.8
348997132021Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1.10
325572592021Interleukin-29 and interleukin-28A induce migration of neutrophils in rheumatoid arthritis.3
338853372021Linkage of Lambda Interferons in Protection Against Severe COVID-19.8
348997132021Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1.10
319960712020A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells.1
322058512020IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro.0
325279252020Type III interferons disrupt the lung epithelial barrier upon viral recognition.232

Citation

Dessen P

IFNL2 (interferon lambda 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45886/js/js/lib/jquery-3.5.1.min.js