IL1R1 (interleukin 1 receptor type 1)

2007-02-01  

Identity

HGNC
IL1R1
LOCATION
2q12.1
LOCUSID
3554
ALIAS
CD121A,D2S1473,IL-1R-alpha,IL1R,IL1RA,P80
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3554
MIM: 147810
HGNC: 5993
Ensembl: ENSG00000115594

Variants:

dbSNP: 3554
ClinVar: 3554
TCGA: ENSG00000115594
COSMIC: IL1R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115594ENST00000409288B8ZZ73
ENSG00000115594ENST00000409329B8ZZ73
ENSG00000115594ENST00000409589B9A040
ENSG00000115594ENST00000409929B8ZZW4
ENSG00000115594ENST00000410023P14778
ENSG00000115594ENST00000413623F8WF92
ENSG00000115594ENST00000422532H7BZM5
ENSG00000115594ENST00000424272B8ZZ73
ENSG00000115594ENST00000428279C9J3W8
ENSG00000115594ENST00000430171C9JQ36
ENSG00000115594ENST00000442590C9JWB2
ENSG00000115594ENST00000450319C9J686
ENSG00000115594ENST00000452403C9JW84

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cytokine-cytokine receptor interactionKEGGko04060
Hematopoietic cell lineageKEGGko04640
MAPK signaling pathwayKEGGhsa04010
Cytokine-cytokine receptor interactionKEGGhsa04060
Hematopoietic cell lineageKEGGhsa04640
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-10 signalingREACTOMER-HSA-6783783
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376340842024ANGPTL3 negatively regulates IL-1β-induced NF-κB activation by inhibiting the IL1R1-associated signaling complex assembly.1
376340842024ANGPTL3 negatively regulates IL-1β-induced NF-κB activation by inhibiting the IL1R1-associated signaling complex assembly.1
371984292023The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia.2
377334482023A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.6
371984292023The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia.2
377334482023A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.6
346478462022IL-1R1 rs6755229 polymorphism is related to death in patients undergoing major surgery who develop septic shock: a retrospective study.0
349234252022Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia.4
349957302022Expression of obesity- and type-2 diabetes-associated genes in omental adipose tissue of individuals with obesity.3
351439412022IL1R1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease.0
354602502022Expression-based Genome-wide Association Study Links OPN and IL1-RA With Newly Diagnosed Type 1 Diabetes in Children.0
346478462022IL-1R1 rs6755229 polymorphism is related to death in patients undergoing major surgery who develop septic shock: a retrospective study.0
349234252022Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia.4
349957302022Expression of obesity- and type-2 diabetes-associated genes in omental adipose tissue of individuals with obesity.3
351439412022IL1R1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease.0

Citation

Dessen P

IL1R1 (interleukin 1 receptor type 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45898/cancer-prone-explorer/gene-explorer/js/lib/bootstrap.min.js