CBX5 (chromobox 5)

2007-02-01  

Identity

HGNC
CBX5
LOCATION
12q13.13
LOCUSID
23468
ALIAS
HEL25,HP1,HP1A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23468
MIM: 604478
HGNC: 1555
Ensembl: ENSG00000094916

Variants:

dbSNP: 23468
ClinVar: 23468
TCGA: ENSG00000094916
COSMIC: CBX5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000094916ENST00000209875P45973
ENSG00000094916ENST00000209875V9HWG0
ENSG00000094916ENST00000439541P45973
ENSG00000094916ENST00000439541V9HWG0
ENSG00000094916ENST00000550411P45973
ENSG00000094916ENST00000550411V9HWG0
ENSG00000094916ENST00000552562F8VNY3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387810282024Bipartite binding interface recruiting HP1 to chromosomal passenger complex at inner centromeres.1
388120602024Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma.1
388959972024Conformational diversity of human HP1α.1
387810282024Bipartite binding interface recruiting HP1 to chromosomal passenger complex at inner centromeres.1
388120602024Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma.1
388959972024Conformational diversity of human HP1α.1
370145692023HP1α promotes the progression of prostate cancer.0
371165792023The local density of H3K9me3 dictates the stability of HP1α condensates-mediated genomic interactions.0
373023602023How to evict HP1 from H3: Using a complex salt bridge.0
370145692023HP1α promotes the progression of prostate cancer.0
371165792023The local density of H3K9me3 dictates the stability of HP1α condensates-mediated genomic interactions.0
373023602023How to evict HP1 from H3: Using a complex salt bridge.0
348720002022Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells.2
352490382022Circ_0037866 Contributes to the Tumorigenesis of Renal Cell Carcinoma by Sequestering miR-384 to Elevate Chromobox 5 Expression.1
365372422022Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding.18

Citation

Dessen P

CBX5 (chromobox 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45904/case-report-explorer/js/favicon/apple-touch-icon.png