NCR3 (natural cytotoxicity triggering receptor 3)

2007-02-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
1C7,CD337,LY117,MALS,NKp30
FUSION GENES

Other Information

Locus ID:

NCBI: 259197
MIM: 611550
HGNC: 19077
Ensembl: ENSG00000204475

Variants:

dbSNP: 259197
ClinVar: 259197
TCGA: ENSG00000204475
COSMIC: NCR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204475ENST00000340027O14931
ENSG00000204475ENST00000376071O14931
ENSG00000204475ENST00000376072O14931
ENSG00000204475ENST00000376073O14931
ENSG00000204475ENST00000376073Q05D23

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
180552292007Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.124
188528792008Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
233453272013Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules.73
156571832005Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias.60
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
187139712008Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy.49
162722872005Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors.46
180920042007Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44.35
253157722014Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack.30

Citation

Dessen P

NCR3 (natural cytotoxicity triggering receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45913/ncr3-(natural-cytotoxicity-triggering-receptor-3)