ANK3 (ankyrin 3)

2007-02-01  

Identity

HGNC
LOCATION
10q21.2
LOCUSID
ALIAS
ANKYRIN-G,MRT37
FUSION GENES

Other Information

Locus ID:

NCBI: 288
MIM: 600465
HGNC: 494
Ensembl: ENSG00000151150

Variants:

dbSNP: 288
ClinVar: 288
TCGA: ENSG00000151150
COSMIC: ANK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151150ENST00000280772Q12955
ENSG00000151150ENST00000355288Q12955
ENSG00000151150ENST00000373815B1AQT1
ENSG00000151150ENST00000373820H0Y3A4
ENSG00000151150ENST00000373827Q12955
ENSG00000151150ENST00000459732A0A087WWI5
ENSG00000151150ENST00000460468D6RF31
ENSG00000151150ENST00000467420H0Y9E9
ENSG00000151150ENST00000474360H0Y8Z4
ENSG00000151150ENST00000486349A0A087X0L3
ENSG00000151150ENST00000502769H0Y951
ENSG00000151150ENST00000503366Q12955
ENSG00000151150ENST00000503925D6RHY3
ENSG00000151150ENST00000506635D6RBY7
ENSG00000151150ENST00000511043H0YA66
ENSG00000151150ENST00000513049D6RFK6
ENSG00000151150ENST00000514197H0YAH5
ENSG00000151150ENST00000610321A0A087WTF3
ENSG00000151150ENST00000610901A0A087WVC2
ENSG00000151150ENST00000612776A0A087WY90
ENSG00000151150ENST00000613207A0A087WTE8
ENSG00000151150ENST00000616444A0A087WZ65
ENSG00000151150ENST00000617800A0A087WX55
ENSG00000151150ENST00000618080A0A087WZ26
ENSG00000151150ENST00000621739A0A087WTP5
ENSG00000151150ENST00000622427A0A087X0B4

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Interaction between L1 and AnkyrinsREACTOMER-HSA-445095
COPI-mediated anterograde transportREACTOMER-HSA-6807878

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187113652008Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.442
187113652008Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.442
159313892005Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.297
176203372007Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos.71
201851492010Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.70
201851492010Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.70
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
170747662007Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells.69
190887392009Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.67
190887392009Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.67

Citation

Dessen P

ANK3 (ankyrin 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45914/ank3