PLSCR1 (phospholipid scramblase 1)

2007-02-01  

Identity

HGNC
PLSCR1
LOCATION
3q24
LOCUSID
5359
ALIAS
MMTRA1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5359
MIM: 604170
HGNC: 9092
Ensembl: ENSG00000188313

Variants:

dbSNP: 5359
ClinVar: 5359
TCGA: ENSG00000188313
COSMIC: PLSCR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188313ENST00000342435O15162
ENSG00000188313ENST00000448787O15162
ENSG00000188313ENST00000462666C9J9P4
ENSG00000188313ENST00000463777F2Z3F2
ENSG00000188313ENST00000468985F2Z3F2
ENSG00000188313ENST00000472349C9JE06
ENSG00000188313ENST00000478267F2Z3F2
ENSG00000188313ENST00000483300H7C5I5
ENSG00000188313ENST00000486631C9J0H3
ENSG00000188313ENST00000487389C9J7K9
ENSG00000188313ENST00000488253F2Z3F2
ENSG00000188313ENST00000489775F2Z3F2
ENSG00000188313ENST00000493432F2Z3F2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
120108042002Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1.47
219583832011Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome.44
153086952004Phospholipid scramblase 1 potentiates the antiviral activity of interferon.43
156110842005Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha.42
125649252003Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane.38
147667532004Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils.35
160913592005Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression.28
120098952002Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.26
153085602004Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation.26
222645142012Phospholipid scramblase 1 mediates type i interferon-induced protection against staphylococcal α-toxin.23

Citation

Dessen P

PLSCR1 (phospholipid scramblase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45949/plscr1-(phospholipid-scramblase-1)