CCL5 (C-C motif chemokine ligand 5)

2007-02-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
D17S136E,RANTES,SCYA5,SIS-delta,SISd,TCP228,eoCP

Other Information

Locus ID:

NCBI: 6352
MIM: 187011
HGNC: 10632
Ensembl: ENSG00000271503

Variants:

dbSNP: 6352
ClinVar: 6352
TCGA: ENSG00000271503
COSMIC: CCL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000271503ENST00000603197P13501
ENSG00000271503ENST00000603197D0EI67
ENSG00000271503ENST00000605140P13501
ENSG00000271503ENST00000605140D0EI67
ENSG00000271503ENST00000605509P13501
ENSG00000271503ENST00000605509D0EI67
ENSG00000271503ENST00000651122A0A494C1Q1

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Prion diseasesKEGGko05020
Prion diseasesKEGGhsa05020
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Interleukin-10 signalingREACTOMER-HSA-6783783

References

Pubmed IDYearTitleCitations
184397512008The inflammatory chemokines CCL2 and CCL5 in breast cancer.186
186782432009Peripheral cytokines profile in Parkinson's disease.122
231525592012Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.118
158909692005Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium.101
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
191562042009IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.100
214864402011Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition.99
224445102012Determinants of asthma after severe respiratory syncytial virus bronchiolitis.89
226377262012CCR5 antagonist blocks metastasis of basal breast cancer cells.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85

Citation

Dessen P

CCL5 (C-C motif chemokine ligand 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45956/ccl5