KRT10 (keratin 10)

2007-02-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
BCIE,BIE,CK10,EHK,K10,KPP
FUSION GENES

Other Information

Locus ID:

NCBI: 3858
MIM: 148080
HGNC: 6413
Ensembl: ENSG00000186395

Variants:

dbSNP: 3858
ClinVar: 3858
TCGA: ENSG00000186395
COSMIC: KRT10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186395ENST00000269576P13645
ENSG00000186395ENST00000635956A0A1B0GVI3

Expression (GTEx)

0
5000
10000
15000
20000
25000

Pathways

PathwaySourceExternal ID
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124270982002Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization.77
207982802010Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10.47
186370392009Effects of extracellular calcium on the growth-differentiation switch in immortalized keratinocyte HaCaT cells compared with normal human keratinocytes.38
185596052008Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection.36
216156742011Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia.34
165050002006A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis.16
212719942011Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis.15
168880102006Autoantibodies from synovial lesions in chronic, antibiotic treatment-resistant Lyme arthritis bind cytokeratin-10.14
182597652008Knockdown of PKD1 in normal human epidermal keratinocytes increases mRNA expression of keratin 10 and involucrin: early markers of keratinocyte differentiation.11
244341522014PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression.11

Citation

Dessen P

KRT10 (keratin 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45972/krt10