REN (renin)

2007-02-01  

Identity

HGNC
REN
LOCATION
1q32.1
LOCUSID
5972
ALIAS
ADTKD4,HNFJ2,RTD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5972
MIM: 179820
HGNC: 9958
Ensembl: ENSG00000143839

Variants:

dbSNP: 5972
ClinVar: 5972
TCGA: ENSG00000143839
COSMIC: REN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143839ENST00000272190P00797
ENSG00000143839ENST00000638118A0A1B0GUZ2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162356187muraglitazarChemicalClinicalAnnotationassociatedPD18794727
PA443886Diabetes MellitusDiseaseClinicalAnnotationassociatedPD18794727
PA443994EdemaDiseaseClinicalAnnotationassociatedPD18794727
PA444528HyperlipidemiasDiseaseClinicalAnnotationassociatedPD18794727

References

Pubmed IDYearTitleCitations
385091492024Plasma renin as a novel prognostic biomarker of sepsis-associated acute respiratory distress syndrome.0
386227202024The role of the brain renin-angiotensin system in Parkinson´s disease.1
385091492024Plasma renin as a novel prognostic biomarker of sepsis-associated acute respiratory distress syndrome.0
386227202024The role of the brain renin-angiotensin system in Parkinson´s disease.1
364782972023The alternative renin-angiotensin-system (RAS) signalling pathway in prostate cancer and its link to the current COVID-19 pandemic.0
364813462023Counter-regulatory renin-angiotensin system in hypertension: Review and update in the era of COVID-19 pandemic.5
375693382023The Relationship between Renin-Angiotensin-Aldosterone System (RAAS) Activity, Osteoporosis and Estrogen Deficiency in Type 2 Diabetes.2
364782972023The alternative renin-angiotensin-system (RAS) signalling pathway in prostate cancer and its link to the current COVID-19 pandemic.0
364813462023Counter-regulatory renin-angiotensin system in hypertension: Review and update in the era of COVID-19 pandemic.5
375693382023The Relationship between Renin-Angiotensin-Aldosterone System (RAAS) Activity, Osteoporosis and Estrogen Deficiency in Type 2 Diabetes.2
330652092021The role of kallikrein-kinin and renin-angiotensin systems in COVID-19 infection.19
331731832021Sequence variants in the renin-angiotensin system genes are associated with isolated multicystic dysplastic kidney in children.1
335087462021Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions.11
336776302021Non-coding Single Nucleotide Variants of Renin and the (Pro)renin Receptor are Associated with Polygenic Diseases in a Bangladeshi Population.1
337500252021Confined placental mosaicism involving multiple de novo copy number variants associated with fetal growth restriction: A case report.2

Citation

Dessen P

REN (renin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45987/img/gene-fusions/css/card-gene.css