RFX1 (regulatory factor X1)

2007-02-01  

Identity

HGNC
RFX1
LOCATION
19p13.12
LOCUSID
5989
ALIAS
EFC,RFX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5989
MIM: 600006
HGNC: 9982
Ensembl: ENSG00000132005

Variants:

dbSNP: 5989
ClinVar: 5989
TCGA: ENSG00000132005
COSMIC: RFX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132005ENST00000254325P22670
ENSG00000132005ENST00000588885K7EIZ8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
202236372010Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells.47
224908692012NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression.42
211927912010RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.25
162878762005Autorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest.21
155283572004Long distance control of MHC class II expression by multiple distal enhancers regulated by regulatory factor X complex and CIITA.18
203815942010Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1.15
245263082014Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma.15
249528742014RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells.15
153340592004Identification of an epigenetically silenced gene, RFX1, in human glioma cells using restriction landmark genomic scanning.14
201899862010Regulation of FGF1 gene promoter through transcription factor RFX1.13

Citation

Dessen P

RFX1 (regulatory factor X1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46019/rfx1