AMBP (alpha-1-microglobulin/bikunin precursor)

2007-02-01  

Identity

HGNC
LOCATION
9q32
LOCUSID
ALIAS
A1M,EDC1,HCP,HI30,IATIL,ITI,ITIL,ITILC,UTI

Other Information

Locus ID:

NCBI: 259
MIM: 176870
HGNC: 453
Ensembl: ENSG00000106927

Variants:

dbSNP: 259
ClinVar: 259
TCGA: ENSG00000106927
COSMIC: AMBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106927ENST00000265132P02760
ENSG00000106927ENST00000466610S4R471
ENSG00000106927ENST00000603230S4R3Y4

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging of heme from plasmaREACTOMER-HSA-2168880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
242114042014Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis.47
118772572002Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties.32
150376152004The ORF3 protein of hepatitis E virus interacts with liver-specific alpha1-microglobulin and its precursor alpha1-microglobulin/bikunin precursor (AMBP) and expedites their export from the hepatocyte.32
177662422007The lipocalin alpha1-microglobulin has radical scavenging activity.28
164072572006Enhanced alpha1 microglobulin secretion from Hepatitis E virus ORF3-expressing human hepatoma cells is mediated by the tumor susceptibility gene 101.27
198799402010Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger alpha(1)-microglobulin in preeclampsia.26
234141802013Urine high and low molecular weight proteins one-year post-kidney transplant: relationship to histology and graft survival.21
156536962005The TSG-6 and I alpha I interaction promotes a transesterification cleaving the protein-glycosaminoglycan-protein (PGP) cross-link.20
161407842005The 41-amino-acid C-terminal region of the hepatitis E virus ORF3 protein interacts with bikunin, a kunitz-type serine protease inhibitor.20

Citation

Dessen P

AMBP (alpha-1-microglobulin/bikunin precursor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46052/ambp