HSPBP1 (HSPA (Hsp70) binding protein 1)

2007-02-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
FES1
FUSION GENES

Other Information

Locus ID:

NCBI: 23640
MIM: 612939
HGNC: 24989
Ensembl: ENSG00000133265

Variants:

dbSNP: 23640
ClinVar: 23640
TCGA: ENSG00000133265
COSMIC: HSPBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133265ENST00000255631Q9NZL4
ENSG00000133265ENST00000433386Q9NZL4
ENSG00000133265ENST00000585698K7EKM6
ENSG00000133265ENST00000585927K7EMM7
ENSG00000133265ENST00000587551K7EQQ0
ENSG00000133265ENST00000587922Q9NZL4
ENSG00000133265ENST00000587959K7EN20
ENSG00000133265ENST00000588971K7ERT9
ENSG00000133265ENST00000593263K7EL16

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152153162004The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator.60
161698502005Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.53
169507972007Hsp70 protects against UVB induced apoptosis by preventing release of cathepsins and cytochrome c in human melanocytes.36
98300371998Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein.27
196596072009Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces.16
191832652009HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease.14
178553532007Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells.12
265386022016HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression.10
288479532017Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.10
248980922014Effect of disulfide crosslinking on thermal transitions and chaperone-like activity of human small heat shock protein HspB1.8

Citation

Dessen P

HSPBP1 (HSPA (Hsp70) binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46091/hspbp1