TXNIP (thioredoxin interacting protein)

2007-02-01  

Identity

HGNC
LOCATION
1q21.1
LOCUSID
ALIAS
ARRDC6,EST01027,HHCPA78,THIF,VDUP1
FUSION GENES

Other Information

Locus ID:

NCBI: 10628
MIM: 606599
HGNC: 16952
Ensembl: ENSG00000265972

Variants:

dbSNP: 10628
ClinVar: 10628
TCGA: ENSG00000265972
COSMIC: TXNIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000265972ENST00000425134Q9H3M7
ENSG00000265972ENST00000582401Q9H3M7
ENSG00000265972ENST00000582401A0A024R4B7

Expression (GTEx)

0
500
1000
1500
2000
2500
3000

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
InflammasomesREACTOMER-HSA-622312
The NLRP3 inflammasomeREACTOMER-HSA-844456

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174724352007TXNIP regulates peripheral glucose metabolism in humans.163
121892052002The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.152
234538062013AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.150
157057782005Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis.123
151287452004Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein.115
167667962006The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange.101
167667962006The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange.101
184583402008Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.101
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
156961992005Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells.76

Citation

Dessen P

TXNIP (thioredoxin interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46111/txnip-(thioredoxin-interacting-protein)