CRHR1 (corticotropin releasing hormone receptor 1)

2007-02-01  

Identity

HGNC
CRHR1
LOCATION
17q21.31
LOCUSID
1394
ALIAS
CRF-R,CRF-R-1,CRF-R1,CRF1,CRFR-1,CRFR1,CRH-R-1,CRH-R1,CRHR,CRHR1L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1394
MIM: 122561
HGNC: 2357
Ensembl: ENSG00000120088

Variants:

dbSNP: 1394
ClinVar: 1394
TCGA: ENSG00000120088
COSMIC: CRHR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120088ENST00000293493A0A0A0MQZ1
ENSG00000120088ENST00000314537P34998
ENSG00000120088ENST00000339069B3TIK8
ENSG00000120088ENST00000347197J9JIC6
ENSG00000120088ENST00000352855P34998
ENSG00000120088ENST00000398285P34998
ENSG00000120088ENST00000535778H0YFR5
ENSG00000120088ENST00000577353P34998
ENSG00000120088ENST00000580876J3QKP8
ENSG00000120088ENST00000580955J3QQR1
ENSG00000120088ENST00000583888J3KSM0
ENSG00000120088ENST00000619154K9J956

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Long-term depressionKEGGko04730
Neuroactive ligand-receptor interactionKEGGhsa04080
Long-term depressionKEGGhsa04730
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD15128701, 18539200, 19210659, 22248724, 27523435
PA165290926fluticasone/salmeterolChemicalClinicalAnnotationassociatedPKPD15128701, 18539200, 19210659, 22248724
PA443450AsthmaDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD15128701, 18539200, 19210659, 22248724, 27523435
PA447196Anxiety DisordersDiseaseClinicalAnnotationassociatedPD17258395
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotation, VariantAnnotationassociatedPD17258395, 17467808, 24422887
PA448681budesonideChemicalClinicalAnnotationassociatedPKPD15128701, 18539200, 19210659, 22248724
PA449673fluoxetineChemicalClinicalAnnotationassociatedPD17258395
PA449686fluticasone propionateChemicalClinicalAnnotationassociatedPKPD15128701, 18539200, 19210659, 22248724
PA451749triamcinoloneChemicalClinicalAnnotationassociatedPKPD15128701, 18539200, 19210659, 22248724
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD24422887

References

Pubmed IDYearTitleCitations
378913932024Genetic Contributions to Attachment Stability Over Time: the Roles of CRHR1 Polymorphisms.0
378913932024Genetic Contributions to Attachment Stability Over Time: the Roles of CRHR1 Polymorphisms.0
362805952023Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease.0
372164332023CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients.0
375436502023Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.1
362805952023Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease.0
372164332023CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients.0
375436502023Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.1
357182172022Relations among CRFR1 and FKBP5 genotype, cortisol, and cognitive function in aging humans: A Project FRONTIER study.4
357182172022Relations among CRFR1 and FKBP5 genotype, cortisol, and cognitive function in aging humans: A Project FRONTIER study.4
328862362021Genetic variants in the glucocorticoid pathway genes and birth weight.1
337259382021Prenatal and postnatal exposure to Tangshan earthquake and CRHR1 gene polymorphism influence risk of sleep disturbance in adulthood.1
342798012021The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta-analysis.1
346178312021Spinal pain in employees exposed to abusive supervision: Evidence of a sex and CRHR1 CTC haplotype interaction.0
328862362021Genetic variants in the glucocorticoid pathway genes and birth weight.1

Citation

Dessen P

CRHR1 (corticotropin releasing hormone receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46116/gene-fusions-explorer/favicon/apple-touch-icon.png