SNCA (synuclein alpha)

2007-02-01 Affiliation

Identity

HGNC

SNCA

LOCATION

4q22.1

LOCUSID

6622

ALIAS

NACP,PARK1,PARK4,PD1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6622
MIM: 163890
HGNC: 11138
Ensembl: ENSG00000145335

Variants:

dbSNP: 6622
ClinVar: 6622
TCGA: ENSG00000145335
COSMIC: SNCA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000145335	ENST00000336904	P37840
ENSG00000145335	ENST00000345009	P37840
ENSG00000145335	ENST00000345009	H6UYS5
ENSG00000145335	ENST00000394986	P37840
ENSG00000145335	ENST00000394989	P37840
ENSG00000145335	ENST00000394989	H6UYS0
ENSG00000145335	ENST00000394991	P37840
ENSG00000145335	ENST00000420646	P37840
ENSG00000145335	ENST00000420646	H6UYS5
ENSG00000145335	ENST00000502987	E7EPV7
ENSG00000145335	ENST00000505199	P37840
ENSG00000145335	ENST00000505199	H6UYS0
ENSG00000145335	ENST00000506244	P37840
ENSG00000145335	ENST00000506691	D6RA31
ENSG00000145335	ENST00000508895	P37840
ENSG00000145335	ENST00000611107	H6UYS7
ENSG00000145335	ENST00000618500	P37840
ENSG00000145335	ENST00000618500	H6UYS0

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Alzheimer's disease	KEGG	ko05010
Alzheimer's disease	KEGG	hsa05010
Parkinson's disease	KEGG	hsa05012
Metabolism of proteins	REACTOME	R-HSA-392499
Amyloid fiber formation	REACTOME	R-HSA-977225

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
14593171	2003	alpha-Synuclein locus triplication causes Parkinson's disease.	1337
15333840	2004	Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy.	614
19651612	2009	Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.	567
11813001	2002	alpha-Synuclein is phosphorylated in synucleinopathy lesions.	530
20798282	2010	Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.	529
16794039	2006	Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.	528
19915576	2009	Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.	471
21700325	2011	Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.	393
21841800	2011	α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.	377
16847063	2006	Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.	364

Citation

Dessen P

SNCA (synuclein alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46121/snca-(synuclein-alpha)