CKAP5 (cytoskeleton associated protein 5)

2007-02-01  

Identity

HGNC
CKAP5
LOCATION
11p11.2
LOCUSID
9793
ALIAS
CHTOG,MSPS,TOG,TOGp,ch-TOG
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9793
MIM: 611142
HGNC: 28959
Ensembl: ENSG00000175216

Variants:

dbSNP: 9793
ClinVar: 9793
TCGA: ENSG00000175216
COSMIC: CKAP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175216ENST00000312055Q14008
ENSG00000175216ENST00000354558Q14008
ENSG00000175216ENST00000525896H0YDX5
ENSG00000175216ENST00000526496E9PQH5
ENSG00000175216ENST00000526876H0YEK7
ENSG00000175216ENST00000527333H0YCF6
ENSG00000175216ENST00000529230Q14008

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
147185662004TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.79
264144022015Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.45
205666842010Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.41
208383832011A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.32
232515352012Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells.31
186633582008Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity.27
234442242013Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.26
188095772008MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics.23
242731642014The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.23
193737732009TOGp regulates microtubule assembly and density during mitosis and contributes to chromosome directional instability.21

Citation

Dessen P

CKAP5 (cytoskeleton associated protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46139/ckap5-(cytoskeleton-associated-protein-5)