CHPT1 (choline phosphotransferase 1)

2007-02-01  

Identity

HGNC
CHPT1
LOCATION
12q23.2
LOCUSID
56994
ALIAS
CPT,CPT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56994
MIM: 616747
HGNC: 17852
Ensembl: ENSG00000111666

Variants:

dbSNP: 56994
ClinVar: 56994
TCGA: ENSG00000111666
COSMIC: CHPT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111666ENST00000229266Q8WUD6
ENSG00000111666ENST00000546873H0YI24
ENSG00000111666ENST00000549128F8W1B3
ENSG00000111666ENST00000549872F8W1B3
ENSG00000111666ENST00000552215H0YI84
ENSG00000111666ENST00000552329H0YHV7
ENSG00000111666ENST00000552351Q8WUD6

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Phosphonate and phosphinate metabolismKEGGko00440
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Phosphonate and phosphinate metabolismKEGGhsa00440
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Metabolic pathwaysKEGGhsa01100
Phosphatidylcholine (PC) biosynthesis, choline => PCKEGGhsa_M00090
Phosphatidylcholine (PC) biosynthesis, choline => PCKEGGM00090
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PCREACTOMER-HSA-1483191

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450163lamivudineChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
319645902020Genetic Polymorphisms of LPCAT1, CHPT1 and PCYT1B and Risk of Neonatal Respiratory Distress Syndrome among a Chinese Han Population.3
329179552020Aberrant activation of super enhancer and choline metabolism drive antiandrogen therapy resistance in prostate cancer.25
319645902020Genetic Polymorphisms of LPCAT1, CHPT1 and PCYT1B and Risk of Neonatal Respiratory Distress Syndrome among a Chinese Han Population.3
329179552020Aberrant activation of super enhancer and choline metabolism drive antiandrogen therapy resistance in prostate cancer.25
246390732015The relation of diet with PAF and its metabolic enzymes in healthy volunteers.19
246390732015The relation of diet with PAF and its metabolic enzymes in healthy volunteers.19
159367202005Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist.5
159367202005Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist.5

Citation

Dessen P

CHPT1 (choline phosphotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46178/gene-fusions-explorer/js/lib/cancer-prone-explorer