ADIPOQ (adiponectin, C1Q and collagen domain containing)

2007-02-01  

Identity

HGNC
LOCATION
3q27.3
LOCUSID
ALIAS
ACDC,ACRP30,ADIPQTL1,ADPN,APM-1,APM1,GBP28
FUSION GENES

Other Information

Locus ID:

NCBI: 9370
MIM: 605441
HGNC: 13633
Ensembl: ENSG00000181092

Variants:

dbSNP: 9370
ClinVar: 9370
TCGA: ENSG00000181092
COSMIC: ADIPOQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181092ENST00000320741Q15848
ENSG00000181092ENST00000320741A8K660
ENSG00000181092ENST00000444204Q15848
ENSG00000181092ENST00000444204A8K660

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Type II diabetes mellitusKEGGko04930
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
Type II diabetes mellitusKEGGhsa04930
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
AMPK inhibits chREBP transcriptional activation activityREACTOMER-HSA-163680
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406954Weight gainDiseaseVariantAnnotationnot associated24953421
PA166123368schizoaffective disorderDiseaseVariantAnnotationnot associated24953421
PA443886Diabetes MellitusDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA447216SchizophreniaDiseaseVariantAnnotationnot associated24953421
PA450970pioglitazoneChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA452233antipsychoticsChemicalVariantAnnotationnot associated24953421

References

Pubmed IDYearTitleCitations
146991282004Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.261
124962572003Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity.252
128785982003Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.223
145572592004Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells.221
129443902003Adiponectin stimulates production of nitric oxide in vascular endothelial cells.206
184315082008Adiponectin regulates albuminuria and podocyte function in mice.194
152390852004Beyond insulin resistance in NASH: TNF-alpha or adiponectin?190
145511512004Adiponectin and metabolic syndrome.186
128296462003Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression.181
200289772010Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype.181

Citation

Dessen P

ADIPOQ (adiponectin, C1Q and collagen domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46188/adipoq