ADIPOQ (adiponectin, C1Q and collagen domain containing)

2007-02-01  

Identity

HGNC
ADIPOQ
LOCATION
3q27.3
LOCUSID
9370
ALIAS
ACDC,ACRP30,ADIPQTL1,ADPN,APM-1,APM1,GBP28
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9370
MIM: 605441
HGNC: 13633
Ensembl: ENSG00000181092

Variants:

dbSNP: 9370
ClinVar: 9370
TCGA: ENSG00000181092
COSMIC: ADIPOQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181092ENST00000320741Q15848
ENSG00000181092ENST00000320741A8K660
ENSG00000181092ENST00000444204Q15848
ENSG00000181092ENST00000444204A8K660

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Type II diabetes mellitusKEGGko04930
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
Type II diabetes mellitusKEGGhsa04930
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
AMPK inhibits chREBP transcriptional activation activityREACTOMER-HSA-163680
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406954Weight gainDiseaseVariantAnnotationnot associated24953421
PA166123368schizoaffective disorderDiseaseVariantAnnotationnot associated24953421
PA443886Diabetes MellitusDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA447216SchizophreniaDiseaseVariantAnnotationnot associated24953421
PA450970pioglitazoneChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA452233antipsychoticsChemicalVariantAnnotationnot associated24953421

References

Pubmed IDYearTitleCitations
373518362024Lower adiponectin is associated with higher anthropometry and insulin resistance but not with low cardiorespiratory fitness in adolescents.0
378313372024Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease.0
378552242024The role of adiposity, adipokines and polymorphisms of leptin and adiponectin in myelodysplastic syndromes.0
378593452024A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin.2
378976832024Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence.2
379239282024Visceral adipose tissue adiponectin predicts excess weight loss after bariatric surgery in females with severe obesity.2
379396782024Correlation of Plasma Adiponectin Levels and Adiponectin Gene Polymorphisms with Idiopathic Atrial Fibrillation.1
379853022024Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients.0
380317952024Potential Association of The Pathogenic Kruppel-like Factor 14 (KLF14) and Adiponectin (ADIPOQ) SNVs with Susceptibility to T2DM.0
381344792024Adiponectin-mediated regulation of the adiponectin cascade in cardiovascular disease: Updates.1
382808322024The role of adiponectin in Alzheimer's disease: A translational review.0
383966932024Preliminary Report on the Influence of Acute Inflammation on Adiponectin Levels in Older Inpatients with Different Nutritional Status.1
384381042024The effect of plasma cytokines on the expression of adiponectin and its receptors in the synovial membrane of joints and the infrapatellar fat pad in patients with rheumatoid arthritis and osteoarthritis.1
384898702024Association of adiponectin and its receptor gene polymorphisms with the risk of coronary heart disease in northern Guangxi.0
384922352024Adiponectin Inhibits the Progression of Obesity-Associated Papillary Thyroid Carcinoma Through Autophagy.1

Citation

Dessen P

ADIPOQ (adiponectin, C1Q and collagen domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46188/case-report-explorer/img/favicon/js/lib/zoomerang.js