HDAC11 (histone deacetylase 11)

2007-02-01  

Identity

HGNC
HDAC11
LOCATION
3p25.1
LOCUSID
79885
ALIAS
HD11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79885
MIM: 607226
HGNC: 19086
Ensembl: ENSG00000163517

Variants:

dbSNP: 79885
ClinVar: 79885
TCGA: ENSG00000163517
COSMIC: HDAC11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163517ENST00000295757Q96DB2
ENSG00000163517ENST00000295757A0A024R2I1
ENSG00000163517ENST00000402259B5MCS3
ENSG00000163517ENST00000402271B5MCQ6
ENSG00000163517ENST00000404040B5MCU6
ENSG00000163517ENST00000404548B5MC52
ENSG00000163517ENST00000405025B5MD06
ENSG00000163517ENST00000405478B5MCV5
ENSG00000163517ENST00000416248C9JMH0
ENSG00000163517ENST00000418189C9J528
ENSG00000163517ENST00000425430F8WF94
ENSG00000163517ENST00000433119Q658J9
ENSG00000163517ENST00000434848C9JBI4
ENSG00000163517ENST00000437379E7ETT9
ENSG00000163517ENST00000446613Q658J9
ENSG00000163517ENST00000455904C9JEC8
ENSG00000163517ENST00000522202Q96DB2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451846valproic acidChemicalPathwayassociated23407051

References

Pubmed IDYearTitleCitations
383663632024HDAC11 Regulates Palmitate-induced NLRP3 Inflammasome Activation by Inducing YAP Expression in THP-1 Cells and PBMCs.0
389399382024[Progress on the involvement of HDAC11 in the regulation of mammalian oocyte maturation and early embryonic development].0
383663632024HDAC11 Regulates Palmitate-induced NLRP3 Inflammasome Activation by Inducing YAP Expression in THP-1 Cells and PBMCs.0
389399382024[Progress on the involvement of HDAC11 in the regulation of mammalian oocyte maturation and early embryonic development].0
376592012023HDAC11: A novel target for improved cancer therapy.2
376592012023HDAC11: A novel target for improved cancer therapy.2
338913742022HDAC11: a multifaceted histone deacetylase with proficient fatty deacylase activity and its roles in physiological processes.21
353322452022HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma.2
356572092022A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker.1
360874292022HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3.2
338913742022HDAC11: a multifaceted histone deacetylase with proficient fatty deacylase activity and its roles in physiological processes.21
353322452022HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma.2
356572092022A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker.1
360874292022HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3.2
336027872021HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness.48

Citation

Dessen P

HDAC11 (histone deacetylase 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46206/gene-fusions/js/lib/jquery-3.5.1.min.js