CGA (glycoprotein hormones, alpha polypeptide)

2007-02-01  

Identity

HGNC
CGA
LOCATION
6q14.3
LOCUSID
1081
ALIAS
CG-ALPHA,FSHA,GPA1,GPHA1,GPHa,HCG,LHA,TSHA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1081
MIM: 118850
HGNC: 1885
Ensembl: ENSG00000135346

Variants:

dbSNP: 1081
ClinVar: 1081
TCGA: ENSG00000135346
COSMIC: CGA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135346ENST00000369582A0A0R4J2F0
ENSG00000135346ENST00000610310A0A087WYZ4
ENSG00000135346ENST00000625577A0A0D9SFJ6
ENSG00000135346ENST00000627148P01215
ENSG00000135346ENST00000627148Q6I9S8
ENSG00000135346ENST00000630630A0A0D9SGA7

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
GnRH signaling pathwayKEGGko04912
Autoimmune thyroid diseaseKEGGko05320
Neuroactive ligand-receptor interactionKEGGhsa04080
GnRH signaling pathwayKEGGhsa04912
Autoimmune thyroid diseaseKEGGhsa05320
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Regulation of lipolysis in adipocytesKEGGhsa04923
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
Reactions specific to the complex N-glycan synthesis pathwayREACTOMER-HSA-975578
Peptide hormone metabolismREACTOMER-HSA-2980736
Peptide hormone biosynthesisREACTOMER-HSA-209952
Glycoprotein hormonesREACTOMER-HSA-209822
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Mineralocorticoid biosynthesisREACTOMER-HSA-193993
Androgen biosynthesisREACTOMER-HSA-193048
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Thyroxine biosynthesisREACTOMER-HSA-209968
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsREACTOMER-HSA-8866910

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
233450942013Age- and gender-specific TSH reference intervals in people with no obvious thyroid disease in Tayside, Scotland: the Thyroid Epidemiology, Audit, and Research Study (TEARS).37
222784202012Serum TSH and risk of papillary thyroid cancer in nodular thyroid disease.36
191968022009Proliferation of uterine natural killer cells is induced by human chorionic gonadotropin and mediated via the mannose receptor.33
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
180636832008Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling.29
211497142010Follicle-stimulating hormone increases bone mass in female mice.28

Citation

Dessen P

CGA (glycoprotein hormones, alpha polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46217/cga